Publications by authors named "I Saleem"
Article Synopsis
- * The review examines various inorganic nanoparticles (like gold and silver) as innovative drug delivery systems, detailing their advantages, disadvantages, and current clinical challenges.
- * Key obstacles for the clinical use of nanoformulations include complex structures, high costs, scalability, and uncertain toxicity, but improvements in biodegradable options and targeting strategies could enhance safety and market viability.
Article Synopsis
- Dengue virus, transmitted primarily by Aedes mosquitoes, poses a major health risk in tropical areas and consists of four serotypes, with DENV-2 identified as the most prevalent in recent studies from Pakistan (2023-2024).
- Research involved analyzing serum samples to identify serotypes and characterized the envelope gene using techniques like nested PCR and sequencing, revealing DENV-2's close relation to strains in China and India.
- The study suggests potential antiviral compounds, specifically Arbidol and Quercetin, and identifies B-cell epitopes for future vaccine development, aiming to improve dengue management strategies in the region.
Objectives: Bacterial infections are a noteworthy global health concern that necessitates the development of new strategies to enhance the potency and efficacy of antibiotics. Rifaximin (RFX), a broad-spectrum antibiotic, exhibits promising antibacterial activity against several bacterial strains. However, its insolubility and impermeability impede the exploitation of its full potential.
View Article and Find Full Text PDFInvasive pulmonary aspergillosis (IPA) is a fatal fungal infection with a high mortality rate. Voriconazole (VCZ) is considered a first-line therapy for IPA and shows efficacy in patients for whom other antifungal treatments have been unsuccessful. The objective of this study was to develop a high-potency VCZ-loaded liposomal system in the form of a dry-powder inhaler (DPI) using the spray-drying technique to convert liposomes into a nanocomposite microparticle (NCMP) DPI, formulated using a thin-film hydration technique.
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