Publications by authors named "I Sakuma"

Craniopharyngiomas, including adamantinomatous (ACP) and squamous papillary (PCP) types, are challenging to treat because of their proximity to crucial pituitary structures. This study aimed to characterize the cellular composition, tumor tissue diversity, and cell-cell interactions in ACPs and PCPs using single-cell RNA sequencing. Single-cell clustering revealed diverse cell types, further classified into developing epithelial, calcification, and immune response for ACP and developing epithelial, cell cycle, and immune response for PCP, based on gene expression patterns.

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Article Synopsis
  • * It involved 312 PAC samples and 315 renin samples, finding that PAC values from CLEIA and liquid chromatography/mass spectrometry/mass spectrometry (LC-MS/MS) were highly correlated, while RIA showed more false positives.
  • * The results indicate that using PAC from CLEIA improves PA detection rates and that weak mineralocorticoids affect PAC measurements, notably in the traditional RIA method.
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This study was aimed to compare the efficacy of two combination tablets of dipeptidyl peptidase-4 (DPP-4) inhibitors and metformin with different dosages, alogliptin/metformin (AM) and vildagliptin/metformin (VM), on glycemic control in patients with type 2 diabetes (T2D). This was a prospective, multicenter, open-label, randomized, parallel group, comparative trial. After a run-in period of treatment with metformin alone, a total of 59 Japanese outpatients with T2D, aged 20-79 years with glycated hemoglobin (HbA1c) levels of 6.

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Purpose: Countertraction is a vital technique in laparoscopic surgery, stretching the tissue surface for incision and dissection. Due to the technical challenges and frequency of countertraction, autonomous countertraction has the potential to significantly reduce surgeons' workload. Despite several methods proposed for automation, achieving optimal tissue visibility and tension for incision remains unrealized.

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Background And Aims: Previous studies have not found a consistent association between circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and the risk of cardiovascular events partly due to measurement methods that cannot distinguish between uncleaved and furin-cleaved forms of PCSK9.

Methods: This is a prespecified sub-study of the REAL-CAD study which is a prospective, multicenter, randomized trial to compare high- versus low-dose statin in patients with stable coronary artery disease (CAD). The primary endpoint was major adverse cerebrovascular and cardiovascular events (MACCE) defined as a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, or unstable angina requiring emergency hospitalization.

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