Publications by authors named "I Saha"
Global burden of cancer pattern in 2020 & prediction to 2040 among older adults.
Indian J Med Res
November 2024
Background & objectives Cancer is one of the leading causes of death among older adults worldwide. The global burden of cancer among older individuals is increasing due to the ageing population. The increasing burden of cancer among older adults will pose significant social and economic challenges for the delivery of healthcare services.
View Article and Find Full Text PDF-(tetra-aryl) picket calix[4]pyrrole 1 featuring -fluorophenyl groups at all four -positions in a -configuration has been synthesized and characterized unambiguously using single-crystal X-ray diffraction analysis. This pre-organized system possesses a deep binding pocket created by the four aryl groups so that anions can be accommodated through anion-π interactions and four-point N-H⋯anion hydrogen bonds. Single-crystal X-ray diffraction analysis of the CsF and TEAF (TEA = tetraethylammonium) complexes of receptor 1 unequivocally confirms the formation of 1 : 1 complexes, revealing the binding modes in the solid state.
View Article and Find Full Text PDFBackground & objectives Although multi-drug therapy has decreased the burden of disease, leprosy is yet to be eliminated. Accelerating progress requires optimal use of existing tools, advanced diagnostic tests, newer drugs, and vaccines. The search for a vaccine with therapeutic and preventive potential is ongoing, but evidence on effectiveness and safety is lacking.
View Article and Find Full Text PDFArticle Synopsis
- Breast cancer is the most prevalent cancer in women, affecting over 2 million annually and leading to 650,000 deaths, but its epigenetic factors are still not fully understood.
- The study used data from The Cancer Genome Atlas and various omics datasets to identify significant features related to breast cancer, narrowing down from 417,486 to 2,701 relevant markers using advanced analytics methods.
- Findings revealed that cancer samples exhibited lower gene expression and higher methylation values, with potential regulatory mechanisms involving transcription factors and 3D chromatin structure, indicating fruitful avenues for new biomarkers and treatments.
Article Synopsis
- - This study aimed to understand how opioid users and their peer educators in Kolkata view treatment and overdose risks related to opioid use.
- - Researchers conducted in-depth interviews with 20 opioid users and six peer educators, identifying key themes around knowledge, treatment effectiveness, and awareness of overdose resources like naloxone.
- - The results highlight a critical need for better training and support for opioid users in recognizing overdoses and administering life-saving interventions, which can inform future policymaking to combat the opioid crisis.