Publications by authors named "I Safra"

Background: Clinical trials (CTs) in children are critical for understanding and treating childhood diseases. However, there trials require prior permission from parents. We evaluated parental attitudes and perceptions regarding the recruitment of their children in CTs.

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An integrated operations planning model for automotive wiring companies is studied to improve synchronization between production activities and inventory flows. These combined factors are growing in significance as they drive the need to take proactive steps in manufacturing and distributing wiring materials within the supply chain. This involves anticipating the requirements of different automotive manufacturers and thereby guaranteeing a consistent, uninterrupted, and punctual provision of raw wiring materials.

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Cockayne syndrome (CS) is a rare autosomal recessive disorder that affects the DNA repair process. It is a progeroid syndrome predisposing patients to accelerated aging and to increased susceptibility to respiratory infections. Here, we studied the immune status of CS patients to determine potential biomarkers associated with pathological aging.

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Article Synopsis
  • - Genetic variations in the gene can inactivate it, leading to a more aggressive form of chronic lymphocytic leukemia (CLL); specifically, the single nucleotide polymorphism (rs1042522:G>C) at codon 72 affects the protein's apoptotic potential.
  • - A study in Tunisia involving 160 CLL patients and 160 matched healthy individuals found that the proline (Pro) variant of the gene is associated with a higher susceptibility to CLL and worse disease outcomes compared to the arginine (Arg) variant.
  • - The Pro variant correlates with more severe CLL conditions, such as advanced Binet stage C, low hemoglobin levels, and low platelet counts, suggesting it may increase both the
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Fetal subdural hematoma is an antenatal finding associated with significant morbidity and mortality. It can occur due to maternal or fetal risk factors, and its management varies based on the underlying cause and the anticipated long-term outcomes. We present a case of warfarin-associated fetal subdural hematoma resulting in a live birth and severe neurodevelopmental delay by 10 years of age.

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