Antiischemic effects of alinidine in paced isolated rat hearts.

Low-flow perfusion of paced (5 Hz) rat heart Langendorff preparation with Tyrode solution for 60 min caused a reduction or disappearance of left ventricular pressure amplitude. After 60 min of low-flow perfusion myocardial concentrations of high energy phosphates, as well as the energy charged potential, were diminished while lactate accumulated. Infusion of alinidine into the perfusate at low-flow conditions, resulted in a mean concentration of 15.

Alinidine antagonizes the myocardial effects of adenosine.

The bradycardiac drug alinidine (2.8-182.3 microM) antagonized the negative inotropic effect of adenosine in isolated left rat atria in a non-competitive fashion.

Uterine relaxation by clenbuterol and fenoterol in conscious rats.

The uterine relaxant activity of clenbuterol and fenoterol was compared in conscious non-pregnant rats with chronically implanted uterine catheters. 0.001-0.