Formation of DNA adducts in tissues of mouse progeny through transplacental contamination and/or lactation after administration of a single dose of ochratoxin A to the pregnant mother.

Ochratoxin A (OTA) is a mycotoxin which has been detected in foods of plant origin, in edible animal tissues, and in human sera, urine, and milk in many countries. OTA is nephrotoxic and carcinogenic in mice and rats and is suspected to play a key role in the etiology of Balkan endemic nephropathy and/or associated urinary tract tumors. In the present study, some early signs of genetic impairment, including the presence of DNA adducts in target tissues from the progeny of mice after administration of a single OTA dose during late pregnancy, have been investigated.

Dominant-lethal mutations and micronucleus induction in male BALB/c, BDF1 and H mice by tobacco smoke.

The mutagenicity of whole tobacco smoke (TS) was examined in male BALB/c, BDF1 and H mice using the dominant lethal and micronucleus tests in bone marrow polychromatic erythrocytes. Male mice (about 80 days old) from the three strains were treated with TS on 5 days/week for 8 weeks. The animals were divided into three groups for every strain: control and two experimental groups.

[The testing for carcinogenicity of a polyethylene terephthalate vascular prosthesis].

A long-term for possible carcinogenicity was conducted by subcutaneous implantation of 1 cm 2 pieces of polyethylenetherophthalate vascular grafts (PET-VG) to 150 BDF1 mice and 120 Syrian golden hamsters of either sex. A false operation was carried out in the same number of animals of control groups. Implantation was performed in nine-week-old animals.