Publications by authors named "I SCHEIBEL"
Transgenerational inheritance of methylmercury and vitamin A-induced toxicological effects in a Wistar rats environmental-based model.
Chemosphere
March 2024
Mercury (Hg) and vitamin A (VitA) are two environmental factors with potential health impacts, especially during pregnancy and early childhood. Fish and seafood may present elevated levels of methylmercury (MeHg), the major Hg derivative, and VitA. This study aimed to evaluate the transgenerational effects of exposure to MeHg and/or VitA on epigenetic and toxicological parameters in a Wistar rat model.
View Article and Find Full Text PDFTreatment with bexarotene, a selective retinoid X receptor (RXR) agonist, significantly improves behavioral dysfunctions in various neurodegenerative animal models. Additionally, it activates neurodevelopmental and plasticity pathways in the brains of adult mice. Our objective was to investigate the impact of RXR activation by bexarotene on adult neural stem cells (aNSC) and their cell lineages.
View Article and Find Full Text PDFArticle Synopsis
- RAGE is a receptor linked to chronic inflammation in diseases and is thought to play a role in neuroinflammation, particularly in conditions like Parkinson's disease (PD) and Alzheimer's disease (AD).
- While RAGE's involvement in Alzheimer's seems clear due to its role in microglial inflammation, studies suggest that its function in PD is more complex and not fully understood.
- The review examines current evidence on RAGE in PD, proposing that its role extends beyond just neuroinflammation to include various cellular mechanisms influencing the disease's development and progression.
Article Synopsis
- The study aimed to identify factors associated with mortality in pediatric patients with childhood-onset systemic lupus erythematosus (cSLE) by analyzing clinical data and determining frequent causes of death.
- Researchers reviewed medical records of 1,528 cSLE patients from 27 centers in Brazil and found that 63 patients died, primarily due to sepsis and opportunistic infections, with significant mortality risks linked to neuropsychiatric lupus and chronic kidney disease.
- Although the overall survival rates for cSLE patients after diagnosis were high (97% at 5 years), the findings highlight the need for better management of high-risk conditions in these patients.
Patient-Reported Outcomes Among Patients Ages Two to Seventeen Years With Polyarticular-Course Juvenile Idiopathic Arthritis Treated With Subcutaneous Abatacept: Two-Year Results From an International Phase III Study.
Arthritis Care Res (Hoboken)
August 2023
Objective: To describe longitudinal changes in patient-reported outcomes (PROs) in children with polyarticular-course juvenile idiopathic arthritis (pJIA) treated with subcutaneous abatacept.
Methods: Secondary analysis of a single-arm, open-label 24-month study of patients ages 6-17 years and 2-5 years. PROs included Childhood Health Assessment Questionnaire-Disability Index (CHAQ-DI), parent global assessment of child well-being (PaGA), pain assessment, and Activity Limitation Questionnaire (ALQ).