Publications by authors named "I S Wallace"
Purpose: To identify the patient acceptable symptom state (PASS) and substantial clinical benefit (SCB) thresholds for hip arthroscopy and provide guidance on how to choose among the thresholds.
Methods: A systematic review of literature was conducted in PubMed and MEDLINE databases in August 2024 using the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Studies with Level I to IV evidence that defined SCB or PASS thresholds for patient-reported outcomes for hip arthroscopy in the setting of intra-articular pathology were included.
Purpose: To identify sex-based differences in pathology, outcomes, and complications after hip arthroscopy for femoroacetabular impingement (FAI), and to compare patient-reported outcomes (PRO) scores between males and females.
Methods: The PubMed and MEDLINE databases were searched in September 2024, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies had data stratified by sex, minimum 2-year patient reported outcome (PRO) scores for hip arthroscopy in the setting of FAI and labral pathology, and a 2014 or later publication date.
Article Synopsis
- James Neel's Thrifty Genotype Hypothesis suggests that genetic traits promoting energy conservation and fat storage were advantageous during resource-scarce periods in human evolution but now contribute to modern health issues like obesity and type 2 diabetes in industrialized societies.
- Despite its popularity and extensive citations, the applicability of the Thrifty Genotype Hypothesis to current human health remains debatable, leading to exploration of other theories such as the Evolutionary Mismatch Hypothesis.
- The text emphasizes the need for new empirical research, particularly through partnerships with transitioning subsistence-level communities, to better understand the impact of evolutionary history on modern cardiometabolic health, using the Orang Asli of Malaysia as a case study.
Article Synopsis
- The stability of the hip joint relies on both bony structures, like the femoral head and acetabulum, and soft tissues, including the acetabular labrum and hip capsule.
- Untreated hip instability can lead to severe conditions such as osteoarthritis due to abnormal force distribution between the joint components.
- Modern hip arthroscopy allows for targeted treatment of soft tissue instability and bony issues while minimizing risks compared to traditional osteotomies, and in severe cases, it can be combined with pelvic osteotomy for better outcomes.
Characterizing DNA methylation patterns is important for addressing key questions in evolutionary biology, geroscience, and medical genomics. While costs are decreasing, whole-genome DNA methylation profiling remains prohibitively expensive for most population-scale studies, creating a need for cost-effective, reduced representation approaches (i.e.
View Article and Find Full Text PDF