Publications by authors named "I S Vogelius"
Article Synopsis
- Diffuse midline glioma (DMG) is a highly aggressive brain cancer in children and young adults, with a poor prognosis of less than 10% survival rate after two years; radiotherapy is a key treatment but only offers short-term benefits.
- The REMIT protocol aims to assess the safety and palliative effectiveness of reirradiation for DMG patients, while monitoring various health indicators, including performance status and quality of life.
- The study will also address patient selection bias and standardization issues, with plans to begin patient inclusion in 2024.
Aims: In patients with locally advanced non-small cell lung cancer (LA-NSCLC), curative-intent radiotherapy (RT) or chemoradiotherapy (CRT) is associated with considerable toxicity, and approximately half of the patients die within two years. A better understanding of early mortality is needed to improve patient selection and guide supportive interventions. In this population-based, nationwide cohort study, we investigated the incidence, temporal distribution, and risk factors of early mortality.
View Article and Find Full Text PDF. The apparent diffusion coefficient (ADC) extracted from diffusion-weighted magnetic resonance imaging (DWI) is a potential biomarker in radiotherapy (RT). DWI is often implemented with an echo-planar imaging (EPI) read-out due to speed, but unfortunately low geometric accuracy follows.
View Article and Find Full Text PDFArticle Synopsis
- Radiation oncology balances the benefits and risks of high doses of ionizing radiation on tumors and normal tissues, which is crucial for childhood cancer survivors (CCS) who may face significant long-term consequences.
- The Pediatric Normal-Tissue Effects in the Clinic (PENTEC) network aims to analyze and compile dose-volume-response relationships related to adverse events in CCS to guide safer radiation therapy decisions.
- Challenges in studying CCS include their rarity, diverse cancer types, increased health risks beyond radiation exposure, variable study methodologies, and the long delay before adverse effects manifest, complicating risk assessments and data synthesis.
Purpose: In this Pediatric Normal Tissue Effects in the Clinic (PENTEC) vision paper, challenges and opportunities in the assessment of subsequent neoplasms (SNs) from radiation therapy (RT) are presented and discussed in the context of technology advancement.
Methods And Materials: The paper discusses the current knowledge of SN risks associated with historic, contemporary, and future RT technologies. Opportunities for research and SN mitigation strategies in pediatric patients with cancer are reviewed.