RhoA Allosterically Activates Phospholipase Cε via its EF Hands.

Phospholipase Cε (PLCε) cleaves phosphatidylinositol lipids to increase intracellular Ca and activate protein kinase C (PKC) in response to stimulation of cell surface receptors. PLCε is activated via direct binding of small GTPases at the cytoplasmic leaflets of cellular membranes. In the cardiovascular system, the RhoA GTPase regulates PLCε to initiate a cardioprotective pathway, but the underlying molecular mechanism is not known.

Cryo-EM Structure of Phospholipase Cε Defines N-terminal Domains and their Roles in Activity.

Phospholipase Cε (PLCε) increases intracellular Ca and protein kinase C (PKC) activity in the cardiovascular system in response to stimulation of G protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). The ability of PLCε to respond to these diverse inputs is due, in part, to multiple, conformationally dynamic regulatory domains. However, this heterogeneity has also limited structural studies of the lipase to either individual domains or its catalytic core.

Emergent symmetry in TbTerevealed by ultrafast reflectivity under anisotropic strain.

We report ultrafast reflectivity measurements of the dynamics of the order parameter of the charge density wave (CDW) in TbTeunder anisotropic strain. We observe an increase in the frequency of the amplitude mode with increasing tensile strain along the-axis (which drives the lattice into > , withandthe lattice constants), and similar behavior for tensile strain along( > ). This suggests that both strains stabilize the corresponding CDW order and further support the near equivalence of the CDW phases oriented in- and-axis, in spite of the orthorhombic space group.

Measurement of the magnetic octupole susceptibility of PrVAl.

Revealing the presence of magnetic octupole order and associated octupole fluctuations in solids is a highly challenging task due to the lack of simple external fields that can couple to magnetic octupoles. Here, we demonstrate a methodology for probing the magnetic octupole susceptibility of a candidate material, PrVAl, using a product of magnetic field H and shear strain ϵ as a composite effective field, while employing an adiabatic elastocaloric effect to probe the response. We observe Curie-Weiss behavior in the obtained octupolar susceptibility down to approximately 3 K.

Anomalous Superfluid Density in a Disordered Charge-Density-Wave Material: Pd-Intercalated ErTe_{3}.

We image local superfluid density in single crystals of Pd-intercalated ErTe_{3} below the superconducting critical temperature T_{c}, well below the onset temperature T_{CDW} of (disordered) charge-density-wave order. We find no detectable inhomogeneities on micron scales. We observe a rapid increase of the superfluid density below T_{c}, deviating from the behavior expected in a conventional Bardeen-Cooper-Schrieffer superconductor, and show that the temperature dependence is qualitatively consistent with a combination of quantum and thermal phase fluctuations.