[Structural brain changes in patients with temporal lobe epilepsy and comorbid depression].

Objective: To assess the morphological features of the brain structures in patients with temporal lobe epilepsy and comorbid depression.

Material And Methods: From 1 January 2017 to 31 December 2020, we studied 80 patients with temporal lobe epilepsy (aged 18-60 years, 38 of whom had comorbid depression) and 48 healthy subjects of comparable age. Magnetic resonance imaging (MRI) of the brain was performed using the epilepsy protocol in a scanner with a magnetic field strength of 1.

[Apathy in depression: a morphometric analysis].

Aim: To study structural correlates of apathy in patients with late-life depression.

Material And Methods: Thirty-five patients (≥60 y.o.

[Patterns of brain functional connectivity in frontal and temporal lobe epilepsies].

Aim: To examine alterations of functional connectivity (FC) of the brain in patients with frontal and temporal lobe epilepsies.

Material And Methods: Forty-three patients, aged 18-55 years, including 32 with temporal lobe epilepsy (TLE) and 11 with frontal lobe epilepsy (FLE), and 32 age/gender-matched healthy controls (HC) underwent structural and functional MRI on 1,5 T scanner. Imaging data were further analysed for functional connectivity characteristics by seed-based and ICA analyses.

[Neuronet restructuring in focal and generalized epilepsy according to resting state fMRI].

Aim: To compare neuronet restructuring in focal and generalized epilepsy.

Material And Methods: Seventy-seven patients, aged from 18 to 65 years, with the diagnosis of epilepsy, including 63 patients with focal epilepsy and 14 with generalized epilepsy, were examined. A control group included 23 healthy people.

[Clinical and neurovisualization characteristics of apathetic depression].

Aim: To study apathetic depression first diagnosed at late age and identify its relation to cognitive and social dysfunction as well as to morphological and functional changes in the brain.

Material And Methods: Thirty-two patients at the age above 60 years with newly diagnosed depressive episode and 15 healthy age-matched volunteers were included in the study. All patients were divided into two groups by the score on the Apathy scale (AS): >14 - depression with apathy (n=21), <14 - depression without apathy (n=11).