Publications by authors named "I S Salonen"
The tumor immune microenvironment (TiME) of human central nervous system (CNS) tumors remains to be comprehensively deciphered. Here, we employed flow cytometry and RNA sequencing analysis for a deep data-driven dissection of a diverse TiME and to uncover noncanonical immune cell types in human CNS tumors by using seven tumors from five patients. Myeloid subsets comprised classical microglia, monocyte-derived macrophages, neutrophils, and two noncanonical myeloid subsets: CD3 myeloids and CD19 myeloids.
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- Prostate cancer treatment resistance is a major challenge, with genomic studies revealing how cancer cells evade therapies, yet the tumor microenvironment's (TME) role remains unclear.
- A study using advanced techniques on samples from 120 patients offers a detailed transcriptomic profile of the prostate TME throughout the treatment process.
- The research highlights a unique cell type called club-like cells that interact with the immune system, suggesting their involvement in inflammation and resistance to androgen deprivation therapy, indicating they could be potential targets for new treatments.
Eutrophication is accelerating the recent expansion of oxygen-depleted coastal marine environments. Several bolivinid foraminifera are abundant in these oxygen-depleted settings, and take up nitrate through the pores in their shells for denitrification. This makes their pore density a possible nitrate proxy.
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- The study focuses on the progression of low-grade diffuse astrocytomas into grade 4 tumors and its impact on patient outcomes, highlighting the need for better understanding to enhance patient care.
- Researchers analyzed genetic data from a cohort of patients with IDH-mutant astrocytomas, revealing significant alterations like increased chromosomal rearrangements and inactivation of key genes related to cell cycle regulation after treatment.
- Results indicate that combined postoperative radiation and chemotherapy, especially temozolomide, may lead to improved survival outcomes, particularly in patients with grade 3 tumors, suggesting a need for more effective treatment strategies.
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- Foraminifera are unicellular eukaryotes crucial to marine ecosystems, affecting biogeochemical cycles and showing distinct habitat preferences based on sediment conditions.
- This study used 16S rRNA gene metabarcoding to analyze the microbiomes of five deep-sea foraminiferal species, revealing their unique microbiomic profiles and significant differences from surrounding sediment bacteria.
- The findings suggest potential symbiotic relationships between specific bacterial groups and foraminiferal species, alongside chloroplast evidence indicating various trophic preferences among them.