Publications by authors named "I S Patel"

Background: Craniosynostosis, a condition involving the premature fusion of cranial sutures, can impair brain development and potentially lead to developmental delays. This study compares open cranial vault remodeling versus endoscopic strip craniectomy treatment for isolated sagittal craniosynostosis, primarily focusing on development outcomes.

Methods: A retrospective cohort study was conducted at a tertiary pediatric surgery center, involving all 45 patients treated surgically for isolated sagittal craniosynostosis from 2013 to 2024.

View Article and Find Full Text PDF

Background: The optimal treatment for ischemic mitral regurgitation (IMR) in patients of non-ST elevation myocardial infarction (NSTEMI) is a debated topic.

Objective: To evaluate the long term outcome on patients with NSTEMI and IMR, particularly emphasizing the comparison of treatments in those with moderate to severe MR.

Methods: We enrolled patients with NSTEMI and classified non/trivial to mild regurgitation as insignificant IMR and moderate to severe regurgitation as significant IMR.

View Article and Find Full Text PDF

Gemtuzumab ozogamicin (GO) is a CD33-targeting antibody-drug conjugate approved for the treatment of CD33-positive de novo and relapsed and refractory acute myeloid leukemia (AML). Subset analyses have demonstrated improved clinical outcomes in patients with favorable-risk disease. It is unclear whether the addition of GO to cytarabine and anthracycline chemotherapy (7+3) improves clinical outcomes compared with other conventional regimens for AML.

View Article and Find Full Text PDF
Article Synopsis
  • - The study aimed to explore how a polygenic risk score (PRS) for QT prolongation (QTc-PRS) is linked to QTc intervals and sudden cardiac death (SCD) in people with and without sleep-disordered breathing (SDB) using data from the UK Biobank.
  • - Results showed that a higher QTc-PRS was connected to longer QTc intervals, with SDB significantly affecting the relationship between QTc-PRS and SCD risk; those with SDB had a much higher risk of SCD.
  • - In particular, Black participants with SDB were found to have a notably high risk of sudden cardiac death, highlighting the importance of SDB as a modifier for genetic risk factors.
View Article and Find Full Text PDF

Informed consent is a crucial requirement of a patient's surgical care but can be a burdensome task. Artificial intelligence (AI) and machine learning language models may provide an alternative approach to writing detailed, readable consent forms in an efficient manner. No studies have assessed the accuracy and completeness of AI-generated consents for aesthetic plastic surgeries.

View Article and Find Full Text PDF