Publications by authors named "I S Muskens"
Background: Meningiomas are the most common primary brain tumor. Though typically benign with a low mutational burden, tumors with benign histology may behave aggressively and there are no proven chemotherapies. Although DNA methylation patterns distinguish subgroups of meningiomas and have higher predictive value for tumor behavior than histologic classification, little is known about differences in DNA methylation between meningiomas and surrounding normal dura tissue.
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- Accelerated aging is a significant characteristic of Down syndrome (DS), leading to health issues like early-onset Alzheimer's disease and premature aging in various body systems.
- The study aimed to determine if signs of epigenetic aging could be detected at birth in newborns with DS, comparing them to newborns without DS.
- Results showed that newborns with DS have an epigenetic age that is approximately 244 days older than their chronological age, suggesting that accelerated aging begins prenatally and could affect health outcomes related to aging in people with DS.
Visual dysfunction in patients with pituitary adenomas is a clear indication for endoscopic endonasal transsphenoidal surgery (EETS). However, the visual outcomes vary greatly among patients and it remains unclear what tumor, patient, and surgical characteristics contribute to postoperative visual outcomes. One hundred patients with pituitary adenomas who underwent EETS between January 2011 and June 2015 in a single institution were retrospectively reviewed.
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