[Effect of antagonists of 5-HT receptors on modulation with serotonin of synaptical activity of projectional neurons of dorsolateral nucleus of rat amygdala].

The work deals with study of role of different serotonin (5-HT) receptor types in the process of synaptic activity modulation of rat dorsolateral amygdale projection neurons with serotonin. The selective antagonist of 5-HT1,2 receptors methylsergide maleate was shown to suppress the 5-HT inhibitory action on amplitude of the postsynaptic currents evoked by glutamate and GABA, whereas the antagonist of 5-HT3,4 receptors SDZ202-557 produced no effect on the above-mentioned 5-HT action. The obtained action indicates that the 5-HT modulatory effect on the projectional neuron synaptic inputs is mediated by 5-HT receptors of the 1 and 2 types.

[Th role of inhibitory interneurons in mechanisms of regulation of sensory synapses formed by thalamic and cortical inputs in pyramidal cells of the dorsolateral amygdala nucleus].

The work deals with study of role of inhibitory interneurons in the process of regulation of sensory currents converging on soma of pyramidal cells of the dorsolateral amygdala nucleus as well as of role of these interneurons in mechanism of regulation of plasticity of amygdalar synapses. It has been shown that the part of the spontaneous inhibitory postsynaptic currents recorded on the dorsolateral amygdale pyramidal cells is relatively high and amounts to about a half of the total amount of the recorded events. Analysis of the evoked postsynaptic responses has shown the interneurons to regulate activity and duration of these responses due to the postsynaptic membrane hyperpolarization as a result of activation of GABA(A)-receptors.

[The role of group II and III metabotropic glutamate receptors in modulation of miniature synaptic activity in frog spinal cord motoneurons].

The results of present work demonstrate significant modulating effects mediated by group II and III mGluRs on miniature postsynaptic potentials (mPSP) of the frog spinal motoneurons. The mode of group II and III mGluRs ligands influences, i. e.