Fc-Effector-Independent in vivo Activity of a Potent Influenza B Neuraminidase Broadly Neutralizing Antibody.

Influenza B virus (IBV) contributes to substantial influenza-mediated morbidity and mortality, particularly among children. Similar to influenza A viruses (IAV), the hemagglutinin (HA) and neuraminidase (NA) of IBV undergo antigenic drift, necessitating regular reformulation of seasonal influenza vaccines. NA inhibitors, such as oseltamivir, have reduced activity and clinical efficacy against IBV, while M2 channel inhibitors are only effective against IAV, highlighting the need for improved vaccine and therapeutics for the treatment of seasonal IBV infections.

Aridity drives coordinated trait shifts but not decreased trait variance across the geographic range of eight Australian trees.

Large intraspecific functional trait variation strongly impacts many aspects of communities and ecosystems, and is the medium upon which evolution works. Yet intraspecific trait variation is inconsistent and hard to predict across traits, species and locations. We measured within-species variation in leaf mass per area (LMA), leaf dry matter content (LDMC), branch wood density (WD), and allocation to stem area vs leaf area in branches (branch Huber value (HV)) across the aridity range of seven Australian eucalypts and a co-occurring Acacia species to explore how traits and their variances change with aridity.

Biometeorological effects on worker absenteeism.

The effects of six biometeorological variables (temperature, precipitation, air pressure, humidity, wind speed, and snow) on plant-wide worker absenteeism rates were investigated using 4 years of daily absence data (n=889). After holding constant temporal variables (years, season, and day of week), and then other biometeorological variables, all but one of the variables under consideration were uniquely and significantly related to absenteeism: temperature (r(partial)=-0.17***), precipitation (r(partial)=0.

Ethical and legal issues.

This article considers the general issues surrounding screening, in particular the problems involved in the collection and use of information derived from screening. Different forms of screening entail particular problems, which have their own ethical complexities. The legal and ethical issues arising from screening are likely to assume greater significance.