[Effects of diphenyl derivatives on electrophoretic mobility of murine T lymphocytes].

The early changes of electrophoretic mobility (EPM) of murine T lymphocytes induced by structural analogues of amixine-dihydrochloryde 4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 1) and dihydrochloryde 2-methoxycarbonil-4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 2) were studied by electrophoresis technique. During the interval 0-2 hours all compounds increased the absolute values of EPM in comparison with control. These changes were of the same kind--distinctions were quantitative.

[Effects of amixine on electrophoretic mobility of murine T lymphocytes].

The amixine-induced early changes in the electrophoretic mobility (EPM) of murine splenic T lymphocytes were studied in vitro by the microelectrophoresis technique. It has been found that T lymphocytes treated with amixine have a greater EPM within the first hours of amixine addition than control cells. This change in EPM depends on the concentration of amixine in the medium and the duration ofamixine exposure.

[Effect of alpha/beta-interferon on electrophoretic mobility of murine T-lymphocytes].

Alpha/beta-Interferon (alpha/beta-IFN)-induced early changes in the electrophoretic mobility (EPM) of murine splenic T lymphocytes were studied by the microelectrophoresis technique. It has been found that alpha/beta-IFN-treated T lymphocytes have a greater EPM than control cells within first hours of alpha/beta-IFN addition. This change in EPM depends on the concentration of alpha/beta-IFN in the medium and the duration of alpha/beta-IFN interaction with the cells.

[Integrative function of nervous cells: role of potassium channels].

Complex processing and integration of the signals observed in neurons are facilitated by a diverse range ofthe gating properties of the ion channels in this cell type, particularly of the voltage-gated potassium channels. A distinctive combination of potassium channels endows neurons with a broad repertoire of the excitable properties and allows each neuron to respond in a specific manner to a given input at a given time. The properties of many potassium channels can be modulated by second messenger pathways activated by neurotransmitters and other stimuli.

[Changes in extracellular K+ concentration modulate properties of voltage dependent K+ channel conductance in PC-12 cells].

The complex processing and integration of signals observed in neurons are facilitated by the diverse range of gating properties of the ion channels in this cell type, particularly the voltage-gated K+ channels (Kv). A distinctive combination of K+ channels endows neurons with a broad repertoire of excitable properties and allows each neuron to respond in a specific manner to a given input at a given time. The properties of many K+ channels can be modulated by second messenger pathways activated by neurotransmitters and other stimuli.