Changes in tissue histology associated with adaptation and acclimation to hypoxia.

Newborn kittens are adapted to hypoxia by having an oxygen department respiration rate. In part, this is due to the structure of the liver which results in a great reduction of oxygen consumption in this organ in response to hypoxia. Older animals possess an oxygen independent respiration rate which is not lost when they acclimate to hypoxia.

Hyperchylomicronemia, oxygen affinity and proton passage across the red cell membrane.

Previously we have shown that HC alters significantly the affinity of hemoglobin for oxygen. This evidence stands in support of earlier investigations presented by Ditzel and Dyerburg (1977). Exposure to 6% chylomicra, slowly produced a decrease in the pO2 of human blood (37 degrees C, at in vivo pH) amounting to a 6.

The effect of hyperchylomicronaemia on oxygen affinity in human blood.

Evidence for a leftward shift of the oxygen dissociation curve in HC patients was first described by Ditzel and Dyerberg. These results were challenged by Robertson et al., who saw no shift using a different technique to obtain P-50.

Control of non-respiratory metabolism by tissue oxygen.

Many intracellular enzymes are activated or inactivated by S-thiolation. The extent of this depends on the local oxygen tension. Thus oxygen should not be considered as an enzyme poison for certain enzymes but as a regulatory of metabolic activity.