Bradykinin-induced shifts in microhemodynamics, lymph production and flow in cat intestine; the effect of gut denervation.

In experiments on anaesthetized cats increased doses of bradykinin were administered intraarterially into an innervated part of the small intestine perfused in situ with constant inflow. It is concluded that the main factor accelerating transcapillary fluid efflux and lymph flow in this region with bradykinin is the rise in permeability of gut capillaries. This is confirmed by elevation in capillary filtration coefficient which takes place on the background of an increase in capillary hydrostatic pressure (when the intestine is naturally blood supplied), as decrease in the latter (when the preparation is perfused under constant inflow).