Publications by authors named "I S Feder"
Introduction: Understanding the mutational landscape of colon cancer (CC) is crucial for targeted therapy development. Microsatellite instability (MSI-H), rat sarcoma (RAS), and B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations (MT) are pivotal markers. Further investigation into clinicopathological features of RAS and BRAF MT in microsatellite stable (MSS) and MSI-H tumors is warranted.
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- Inhalation of asbestos can lead to long-term lung diseases as asbestos bodies form with the help of immune cells called macrophages, often taking decades to manifest after exposure.
- This review focuses on methods for detecting asbestos bodies in lung tissue, the development of diagnostic criteria, and evaluates the strengths and weaknesses of various detection techniques.
- While asbestos use is now heavily restricted globally, including a complete ban in Europe, risks remain from past exposure, especially during renovations or improper handling of materials containing asbestos.
Purpose: Microsatellite instability (MSI) due to mismatch repair (MMR) defects accounts for 15-20% of colon cancers (CC). MSI testing is currently standard of care in CC with immunohistochemistry of the four MMR proteins representing the gold standard. Instead, label-free quantum cascade laser (QCL) based infrared (IR) imaging combined with artificial intelligence (AI) may classify MSI/microsatellite stability (MSS) in unstained tissue sections user-independently and tissue preserving.
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