[Detection of novel genetic markers of susceptibility to preeclampsia based on an analysis of the regulatory genes in the placental tissue].

Regulatory single nucleotide polymorphisms (rSNPs) are the least-studied group of SNP; however, they play an essential role in the development of human pathology by altering the level of candidate genes expression. In this work, we analyzed 29 rSNPs in 17 new candidate genes associated with preeclampsia (PE) according to the analysis of the transcriptome in placental tissue. Three ethnic groups have been studied (yakut, russian, and buryat).

[SKEWED X-CHROMOSOME INACTIVATION IN HUMAN MISCARRIAGES].

Sex ratio in first trimester of pregnancy is skewed due to preferential elimination of female embryos. It could be resulted from aberrant X-chromosome inactivation. X-chromosome inactivation was analyzed in extraembryonic tissues of miscarriages and induced abortions with 46, XX karyotype.

Clinical study of the efficiency of Poetam in the treatment of the anemic syndrome in pubertal uterine hemorrhages.

Clinical study of the efficiency of Poetam (affinity-purified antibodies to recombinant human erythropoietin) in the treatment of anemia in patients with pubertal uterine hemorrhages proved that combined therapy with Poetam and iron preparation normalized erythron parameters, structural and metabolic status of erythrocytes, and ferrokinetic parameters of the peripheral blood sooner than monotherapy with Poetam or sorbifer.

[A pathogenetic model of cerebral palsy in children born to mothers with antiphospholipid syndrome].

A pathogenetic model of infantile cerebral palsy caused by maternal antiphospholipid (APS) syndrome has been elaborated. Thirty-two children with cerebral palsy born to mothers with clinical signs of APS have been studied. The basic clinical feature of cerebral palsy in children was the prevalence of the double hemiplegic form, the absence of severe cognitive disorders, global muscular hypotrophy, rapid contracture formation and a tendency to frequent respiratory diseases.

[Perinatal aspects of serological diagnosis in urogenital chlamydiosis].

The pregnancy course, labor, delivery and early neonatal period were studied in pregnant women with Chlamydia trachomatis infection as well as in their children. The levels of specific antibodies to Chlamydia trachomatis pgp 3 plasmid protein in maternal sera as well as perinatal complications were comparatively analyzed. According to the results, examination of anti-pgp3 antibodies is a highly specific and useful tool for the detection of Chlamydia trachomatis infection at its active stage in pregnant women.