[Association of the structure of the glucocorticoid receptor and single nucleotide gene polymorphisms with metabolic disorders].

Glucocorticoid therapy is widely used in the treatment of various pathologies. Sensitivity to glucocorticoids  (GC) has a serious impact not only on the effectiveness of their action, but also on the severity of side effects, the formation of risk factors and the development  of cardiovascular diseases (CVD). Variability of sensitivity to GC causes different phenotypes and severity of metabolic disorders underlying  CVD.

[Association between depression and metabolic syndrome--a two-way street].

The study with the use of the CES-D scale revealed the combination of depression and metabolic syndrome in 24% of the examined patients. The HADS scale showed depression in 16% of the interviewed patients. Based on the two scales, depression was documented in 32% of the patients.

[Melatonin as a regulator of metabolism].

High prevalence of metabolic syndrome (MS) necessitates elucidation of its causes. Disturbed melatonin synthesis is supposed to be one of them. This work was aimed at studying melatonin (M) secretion in MS and its influence on the main symptoms of MS.

[Melatonin and metabolic syndrome: is there an association?].

The basis for the current view of the mechanisms for regulating metabolic processes is the hypothesis proposed by the United Kingdom scientists E. Scott and P. Grant that evolutionary fixed adaptation to seasonal environmental changes is impaired.

[Arterial hypertension and metabolic disorders].

Combination of arterial hypertension (AH) and metabolic disorders accelerates development of organic lesions in target organs. As shown in recent prospective studies, myocardial hypertrophy rate closely correlated with severity of metabolic disturbance. The thickness of interventricular septum and posterior wall show stronger dependence of severity of metabolic disorders than left ventricular density while left atrial enlargement is correlates with fasting glycemia and excess body mass.