Publications by authors named "I S Christophersen"
Article Synopsis
- - The study examined the prevalence and healthcare burden of early-onset atrial fibrillation (AF) in Norway, focusing on sex differences, using a nationwide healthcare database from 2006-2019.
- - In 2019, 10,925 residents had early-onset AF, with a prevalence of 0.34% (26.3% women), and an average of one primary care consultation per year, showing significant variation in healthcare needs between genders.
- - Findings highlighted a low prevalence of early-onset AF and substantial differences in healthcare utilization between men and women, suggesting the need for more detailed research on age-related and sex-based healthcare requirements.
Article Synopsis
- * The 2023 ACC/AHA guidelines recommend genetic testing for AF patients aged 45 or younger to enhance personalized care and prognosis by identifying specific genetic defects.
- * Challenges in genetic testing for AF include interpreting uncertain results, financial and insurance barriers, and the need for improved training and standardization in testing procedures.
We showed an association between atrial fibrillation and rare loss-of-function (LOF) variants in the cardiac splicing regulator RBM20 in 2 independent cohorts. In a rat model with loss of , we demonstrated altered splicing of sarcomere genes (, , , and ), and differential expression in key cardiac genes. We identified altered sarcomere and mitochondrial structure on electron microscopy imaging and found compromised mitochondrial function.
View Article and Find Full Text PDFBackground And Aims: The benefit of oral anticoagulant (OAC) therapy in atrial fibrillation (AF) and intermediate stroke risk is debated. In a nationwide Norwegian cohort with a non-sex CHA2DS2-VASc risk score of one, this study aimed to investigate (i) stroke and bleeding risk in AF patients with and without OAC treatment, and (ii) the risk of stroke in non-anticoagulated individuals with and without AF.
Methods: A total of 1 118 762 individuals including 34 460 AF patients were followed during 2011-18 until ischaemic stroke, intracranial haemorrhage, increased CHA2DS2-VASc score, or study end.
Feasibility of Patient-Managed ECG Recordings to Detect the Time of Atrial Fibrillation Recurrence after Electrical Cardioversion: Results from the PRE-ELECTRIC Study.
Cardiology
August 2023
Background: Electrical cardioversion (ECV) is a common procedure to terminate persistent atrial fibrillation (AF). The recurrence rate is high, and the patients often fail to recognize AF recurrence.
Objectives: The aim of the study was to evaluate the feasibility of patient-managed electrocardiography (ECG) to detect the time to AF recurrence after ECV.