[The use of laser Doppler flowmetry for the estimation of the influence of intranasal medications on microcirculation in nasal cavity mucosa].

Aim Of The Study: to investigate the influence of various intranasal medications on the microcirculatory bed in nasal cavity mucosa using the original method of laser Doppler flowmetry.

Methods: this comprehensive study of the influence of intranasal medicines on nasal cavity mucosa using laser Doppler flowmetry was designed to evaluate the mucociliary clearance, breathing efficiency of the nose, and subjective symptoms of its impairment. The outcomes of a single application of intranasal medications were estimated in 90 rhinologically healthy subjects; in 15 of them, the micrcirculatory blood flow in the nasal cavity was investigated in the early postoperative period with the use of intranasal decongestants and irrigation products.

[Production of cloned bovine embryos by somatic cell transfer into enucleated zona-free oocytes].

Cloned bovine embryos were produced at the blastocyst stage. Prior to enucleation, oocytes were freed from the zona pellucida. Fibroblasts isolated from the bovine fetus were used as nuclear donors.