Spatial variations of ascidian diets in a glacial retreated fjord of the West Antarctic Peninsula.

The impacts of glacial retreat on diets of ascidians, one of the filter feeders and a major component of the benthic-pelagic energy pathway, remain unclear. We analyzed carbon and nitrogen stable isotopes of four dominant ascidian species and five potential food sources in Marian Cove, a deglaciating fjord in West Antarctica. Microphytobenthos was a major food source for ascidians regardless of proximity to the glacier, but phytoplankton contribution decreased closer to the glacier.

Phase II Study of Acalabrutinib, Venetoclax, and Obinutuzumab in a Treatment-Naïve Chronic Lymphocytic Leukemia Population Enriched for High-Risk Disease.

Purpose: The AMPLIFY trial recently established fixed-duration acalabrutinib, venetoclax, and obinutuzumab (AVO) as a new standard-of-care option for patients with previously untreated chronic lymphocytic leukemia (CLL) with wild-type ; however, due to the chemoimmunotherapy control arm, AMPLIFY excluded patients with high-risk aberration, for whom current standards of care are continuous Bruton tyrosine kinase inhibitor therapy or alternatively fixed-duration venetoclax-based doublets. AVO has not previously been evaluated in patients with CLL with aberration.

Methods: This investigator-sponsored, multicenter, phase II study enrolled patients with treatment-naïve CLL enriched for high-risk CLL, defined by aberration (ClinicalTrials.

Perceived age estimation from facial image and demographic data in young and middle-aged South Korean adults.

Biological age is an indicator of whether an individual is experiencing rapid, slowing, or normal aging. Perceived age is highly correlated with biological age, which reflects health appraisal and is often used as a clinical marker of aging. Perceived age has been reported as an important indicator of biological age and general health status, not only in older adult populations but also in young and middle-aged adults.

PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity.

Adipose tissue regulates energy homeostasis and metabolic function, but its adaptability is impaired in obesity. In this study, we investigate the impact of acute PPARγ agonist treatment in obese mice and find significant transcriptional remodeling of cells in the stromal vascular fraction (SVF). Using single-cell RNA sequencing, we profile the SVF of inguinal and epididymal adipose tissue of obese mice following rosiglitazone treatment and find an induction of ribosomal factors in both progenitor and preadipocyte populations, while expression of ribosomal factors is reduced with obesity.

Explainable predictions of a machine learning model to forecast the postoperative length of stay for severe patients: machine learning model development and evaluation.

Background: Predicting the length of stay in advance will not only benefit the hospitals both clinically and financially but enable healthcare providers to better decision-making for improved quality of care. More importantly, understanding the length of stay of severe patients who require general anesthesia is key to enhancing health outcomes.

Objective: Here, we aim to discover how machine learning can support resource allocation management and decision-making resulting from the length of stay prediction.