Computer model study of electrocardiologic manifestations in asymmetric left ventricular hypertrophy.

Electrocardiologic criteria of left ventricular enlargement do not take into consideration the eventuality of asymmetric hypertrophy. Since experimental techniques for production of this condition are not available, computer modeling was utilized to study its electrocardiologic manifestations. A computer model of human ventricles with analytically defined geometry, consisting of 142,000 elements (1.

Effect of different sources of ventricular repolarization heterogeneity on the resultant cardiac vectors. A model study.

The computer model of ventricular activation was used to study the effects of eventual differences in the repolarization pattern between the right and the left ventricle, as well as between the apical and the basal parts of the ventricles. All changes in model action potential durations (APDs) were performed in the range corresponding to the APD variability measured in myocytes. The vectorcar-diographical spatial T loop was very sensitive on the changes in the right to left ventricular gradient of APD, while the similar changes in the apico-basal gradient of APD influenced the T loop minimally.