Publications by authors named "I Rubic"

Obesity is defined as the excessive accumulation of adipose tissue and is currently the most common disease in cats. Similarly to humans, obesity negatively impacts the health and welfare of cats, predisposing them to many other disorders. The objective of this study was to compare the serum proteomes of normal-weight and overweight/obese cats, aiming to gain insights into the physiopathology of feline obesity and potentially identify new biomarkers.

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Deep proteomic analyses identified, in total, 159 master proteins (with 1% FDR and 2 unique peptides) from 26 protein families in the venom of Data are available via ProteomeXchange with the identifier PXD056495. The relative abundance of PLA2s is 11.60% of the crude venom, of which 4.

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Article Synopsis
  • Parkinson's disease (PD) exhibits a wide range of symptoms, complicating the translation of treatment efficacy from animal models to humans, suggesting that current models may not fully capture all PD characteristics.
  • This project investigates whether metabolic dysfunction, induced by administering streptozotocin directly into the striatum of rats, can mimic the symptoms of PD typically seen in patients, focusing on cognitive and motor functions.
  • Results showed that rats given streptozotocin bilaterally experienced significant motor and cognitive impairments alongside disrupted brain metabolism, indicating that this method could provide a better animal model for studying PD and testing new therapies.
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Liver fluke infections are acknowledged as diseases with global prevalence and significant implications for both veterinary and public health. The large American liver fluke, , is a significant non-native parasite introduced to Europe, threatening the survival of local wildlife populations. The aim of this study was to analyze differences in the serum proteome and metabolome between -infected and control red deer.

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Equine gastric ulcer syndrome (EGUS) is a common condition in horses. This study explores the use of liquid proteomics to identify new biomarkers in saliva and serum to monitor EGUS treatment. The proteomes of horses with EGUS before and after a successful treatment with omeprazole were analysed.

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