Publications by authors named "I Rodriguez-Hernandez"
Diagnostic Algorithm for Intracranial Lesions in the Emergency Department: Effectiveness of the Relative Brain Volume and Hounsfield Unit Value Measured by Perfusion Tomography.
Cureus
June 2024
Article Synopsis
- Early treatment of intracranial lesions is crucial but challenging to differentiate, as each type requires different treatment strategies; Cerebral computed tomography perfusion (CTP) imaging is effective in visualizing and quantifying brain lesions' vascularity.
- This study evaluated the effectiveness of Hounsfield units (HU) and CTP in distinguishing various intracranial space-occupying lesions over a five-year period, involving 244 patients with conditions including glioblastomas, primary central nervous system lymphoma, metastases, and abscesses.
- Results indicated that combining rCBV and HU measurements enhances diagnostic accuracy for differentiating lesions, and the simplicity and availability of CTP make it a valuable tool for diagnosing and managing brain tumors.
Background: Postsurgical spinal infections are a severe complication and a challenge to the neurosurgeon due to their complex management. Revision surgeries and the removal of hardware are usually necessary. Recently, advances in nuclear medicine have made it possible to employ radiotracers to identify infections.
View Article and Find Full Text PDFMetastasis involves dissemination of cancer cells away from a primary tumour and colonization at distal sites. During this process, the mechanical properties of the nucleus must be tuned since they pose a challenge to the negotiation of physical constraints imposed by the microenvironment and tissue structure. We discovered increased expression of the inner nuclear membrane protein LAP1 in metastatic melanoma cells, at the invasive front of human primary melanoma tumours and in metastases.
View Article and Find Full Text PDFOver 80% of patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed at a late stage and are locally advanced or with concurrent metastases. The aggressive phenotype and relative chemo- and radiotherapeutic resistance of PDAC is thought to be mediated largely by its prominent stroma, which is supported by an extracellular matrix (ECM). Therefore, we investigated the impact of tissue-matched human ECM in driving PDAC and the role of the ECM in promoting chemotherapy resistance.
View Article and Find Full Text PDFCell migration is essential for many biological processes, while abnormal cell migration is characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to-mesenchymal transition (EMT), and mesenchymal cells increase migration speed by adopting amoeboid features. This review highlights how amoeboid behaviour is not merely a migration mode but rather a cellular state - within the EMT spectra - by which cancer cells survive, invade and colonise challenging microenvironments.
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