GWAS and 3D chromatin mapping identifies multicancer risk genes associated with hormone-dependent cancers.

Hormone-dependent cancers (HDCs) share several risk factors, suggesting a common aetiology. Using data from genome-wide association studies, we showed spatial clustering of risk variants across four HDCs (breast, endometrial, ovarian and prostate cancers), contrasting with genetically uncorrelated traits. We identified 44 multi-HDC risk regions across the genome, defined as overlapping risk regions for at least two HDCs: two regions contained risk variants for all four HDCs, 13 for three HDCs and 28 for two HDCs.

Social determinants of participation in genetic research among Puerto Ricans and in the Puerto Rican diaspora.

Puerto Ricans are underrepresented in genetic research. This underrepresentation denies Puerto Ricans the benefit from therapeutic developments that could mitigate health disparities arising from conditions for which genetically-derived treatments exist. The Puerto Rican diaspora, especially post-2017 due to economic and environmental crises, has expanded within the USA.

A review of empirical treatments focused on mind-body and spiritually grounded complementary practices for moral injury among veterans.

Investigators have called for mind-body practices and spiritual and religious approaches for the treatment of moral injury in veterans. Programs and interventions that use mindfulness, meditation, spirituality, prayer, and other techniques span different academic disciplines and can be difficult for investigators and clinicians to identify but are important for those who work with veterans with moral injury. This paper reports a review of a systematic search that identified 12 empirical studies from eight databases (i.