A brief history of toxicology in France during the last two centuries (1789-1989).

The history of toxicology in France over the last two centuries has been marked by numerous authors who have progressively broadened the fields of investigation: initially concerned with criminal or accidental poisonings, they have also taken an interest in the environment, workers' health, doping and illicit products, the dangers of radioactivity or combat gases, the risks associated with drugs, etc. Often pharmacists, these toxicology experts were specialists in analytical chemistry and developed numerous methods to refine the detection and characterization of potentially toxic products, and to better understand the mechanisms of toxicity produced by these substances.

Study of a more than a hundred years old theriac jar' content: A famous thousand-year-old counter-poison.

The purpose of this article is to study the content of a 19th century white porcelain pot from the Pochet-Desroche fabric, offered to the National Order of Pharmacists and probably containing theriac. The aim is to identify the active ingredients of any substances that may still be present and to try to determine the preparation period of the panacea. All the analyzes were carried out according to the reference current methods.

[Antoine Augustin Parmentier (1737-1813): military pharmacist, humanist and scholar].

From "Frison" pharmacy of his district, Sainte Croix square in Montdidier, where he learned the trade of a pharmacist when he was 15 years old, to the General Inspectorate of the health service of Army responsability he helds from the 1st Germinal, Year IV until his death, Antoine Augustin Parmentier was both an humanist and anerudite scholar even if often, posterity and legend reduce his image only to that of"the inventor" of the most common Solanaceae. His work, more than 189 publications, and his innovative ideas, made advancing scientific knowledge including food chemistry and nutritional health but also in various other areas: blood analysis, preparation of drugs..

Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos.

Studies in mice and guinea pigs have shown that albumin is a new biomarker of organophosphorus toxicant (OP) and nerve agent exposure. Our goal was to determine whether OP-labeled albumin could be detected in the blood of humans exposed to OP. Blood from four OP-exposed patients was prepared for mass spectrometry analysis by digesting 0.