Publications by authors named "I Reymundo Cuesta"
Sindbis virus (SINV), is an of the family . This zoonotic arbovirus is transmitted by mosquitoes, primarily from the genus, with bird species acting as amplifying vertebrate hosts. Occasionally it can also affect humans that are accidental hosts.
View Article and Find Full Text PDFArticle Synopsis
- Fanconi anemia (FA) is a rare genetic disorder marked by varying symptoms and significant chromosome fragility, leading to severe health issues like cancer and bone marrow failure.
- The Spanish Registry of Patients with FA gathered data from 227 patients over 30 years, revealing an 86% cumulative cancer incidence by age 50, with outcomes differing based on chromosome fragility and specific gene mutations.
- Findings suggest that patients with mutations allowing some protein function (genetic hypomorphism) tend to have better health outcomes, indicating potential for new therapies that could enhance mutant FA protein function to improve patient prognosis.
Binder jetting 3D printing is an additive manufacturing technique based on the creation of a part through the selective bonding of powder with an adhesive, followed by a sintering process at high temperature to densify the material and produce parts with acceptable properties. Due to the high initial porosity in the material after sintering, which is typically around 5%, post-sintering treatments are often required to increase the material density and enhance the mechanical and fatigue properties of the final component. This paper focuses on the study of the benefits of hot isostatic pressing (HIP) after sintering on the mechanical and fatigue properties of a binder jetting Ti-6Al-4V alloy.
View Article and Find Full Text PDFBackground: Bacteroides fragilis, an anaerobic gut bacterium and opportunistic pathogen, comprises two genetically divergent groups (or divisions) at the species level. Differences exist both in the core and accessory genomes and the beta-lactamase genes, with the cephalosporinase gene cepA represented only in division I and the carbapenemase gene cfiA only in division II.
Methods: Multidrug resistance in a clinical B.
Article Synopsis
- The 2023 monkeypox epidemic originated from a specific lineage of the monkeypox virus traced back to Nigeria in 1971, with a subclade IIb showing higher person-to-person transmission rates due to genomic changes.
- Researchers used advanced techniques to analyze the genome of the monkeypox virus from the current epidemic, highlighting significant variations in low-complexity regions (LCRs) that are often overlooked.
- The study found that variations in LCRs may influence the expression and function of key poxvirus genes, suggesting that future genome studies should focus on these regions to better understand differences in the virus's behavior.