Publications by authors named "I Reiner"
Article Synopsis
- Depression is linked to a higher risk of developing type 2 diabetes, with the study assessing the impact of current and persistent depressive symptoms on diabetes risk over a five-year period.
- The analysis of data from over 15,000 participants indicated that current (recent) depression significantly increases the risk of developing type 2 diabetes, while a past history of depression alone did not show a notable effect.
- The effect of depression on diabetes risk was similar for both men and women, suggesting that gender does not significantly modify this association.
Cancer poses a significant global health challenge, with predictions of increasing prevalence in the coming years due to limited prevention, late diagnosis, and inadequate success with current therapies. In addition, the high cost of new anti-cancer drugs creates barriers in meeting the medical needs of cancer patients, especially in developing countries. The lengthy and costly process of developing novel drugs further hinders drug discovery and clinical implementation.
View Article and Find Full Text PDFIntroduction: There are several pathologic mechanisms involved in diabetic nephropathy, but the role of oxidative stress seems to be one of the most important. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of antidiabetic drugs that might also have some other effects in addition to lowering glucose. The aim of this study was to evaluate the possible effects of the SGLT2 inhibitor empagliflozin on oxidative stress and renal function in diabetes.
View Article and Find Full Text PDFBackground: The present study aimed to investigate how depressive symptoms affect bodyweight change (gain and loss), and how this association is intertwined with other psychosocial and biomedical factors in the adult general population.
Methods: In a population-based, prospective, observational single-center cohort study in the Rhine-Main-Region, Germany (Gutenberg Health Study GHS) with N = 12,220 participants, we analyzed baseline and five year follow-up data with logistic regressions separately for bodyweight gain and loss (vs. stable bodyweight).