Publications by authors named "I Rego-Garcia"
Neuropathological Heterogeneity of Dementia Due to Combined Pathology in Aged Patients: Clinicopathological Findings in the Vallecas Alzheimer's Reina Sofía Cohort.
J Clin Med
November 2024
Article Synopsis
- Recent research on late-life dementia highlights both neurodegenerative and vascular conditions contributing to the varied symptoms in patients, utilizing the Vallecas Alzheimer's Reina Sofía (VARS) cohort with over 550 participants and associated brain donations.
- The study focused on 167 patients, primarily older women (79%) with an average age of 88, and found a significant presence of the ApoE-e4 gene variant (43%).
- The main findings revealed that 79.6% had Alzheimer's disease, with a high prevalence of other conditions like vascular dementia and Lewy body dementia, and over 71.1% of the patients showed multiple neuropathological findings, indicating the complexity of dementia in this cohort.
Introduction: The Fototest and Mini-Cog include all the domains that are necessary in a cognitive assessment. This study aims to evaluate the diagnostic accuracy of the combined use of both instruments for detecting cognitive impairment.
Methods: We performed a phase III diagnostic accuracy study with 2 independent samples: STUDY, which included 448 participants randomly allocated to 2 datasets (BASE [80%] and TEST [20%]); and EXTERNAL, which included 61 participants.
Introduction And Objectives: This study aims to assess and compare the diagnostic performance of brief cognitive tests for cognitive impairment (CI) screening recommended by the Spanish guidelines for the integral care of people with Alzheimer's disease and other dementias.
Material And Methods: We performed a phase iii study into the accuracy of diagnostic tests, including patients with suspected CI in a primary care setting. All patients completed the Mini-Mental State Examination (MMSE), the Mini Examen Cognoscitivo (MEC), the Short Portable Mental Status Questionnaire (SPMSQ), the Memory Impairment Screen (MIS), the Clock Drawing Test (CDT), the Eurotest, the Fototest, and the Memory Alteration Test (M@T).
Introduction And Objectives: The Mini-Cog is a very brief, widely used cognitive test that includes a memory task and a simplified assessment of the Clock Drawing Test (CDT). There is not a formal evaluation of the Mini-Cog test in Spanish. This study aims to analyse the diagnostic usefulness of the Mini-Cog and CDT for detecting cognitive impairment (CI).
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