Publications by authors named "I Reffo"
Objectives: Mid-regional pro-adrenomedullin (MR-proADM) and monocyte CD169 (CD169) are valuable prognostic indicators of severe COVID-19.
Methods: We assessed the predictive ability of a single measurement of MR-proADM and CD169 at emergency department (ED) admission to forecast in-hospital and 60-day mortality in adult COVID-19 patients. We analyzed clinical and laboratory data, with in-hospital mortality as the primary endpoint and 60-day mortality as the secondary endpoint.
S. aureus bacteremia with acute transverse myelitis case report: Utility of molecular techniques.
J Infect Chemother
September 2024
Article Synopsis
- A 60-year-old man experienced bacteremia and acute transverse myelitis (ATM) due to Staphylococcus aureus, presenting with symptoms like high fever, quadriplegia, and respiratory failure, without a clear source of infection.
- Bacterial ATM is rare and often difficult to diagnose, especially when caused by isolated infections in the spinal cord.
- The rapid diagnosis in this case resulted from teamwork among clinicians, infectious disease specialists, and microbiologists, along with advanced testing methods on cerebral spinal fluid (CSF).
Staphylococcus aureus bacteremia presents clinical complexities, with prolonged duration associated with unfavorable outcomes. This research delves into unconventional treatments, such as combinations involving daptomycin, oxacillin, ceftaroline, and fosfomycin, with the aim of swiftly sterilizing bloodstream infection to reduce complications. Our examination of 30 MSSA bacteremia patients with infective endocarditis uncovers differing results between single-agent therapies (oxacillin or daptomycin) and combined treatment plans.
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- Clostridium perfringens can cause severe infections from abdominal issues, leading to hemolysis and potentially fatal outcomes, necessitating urgent multispecialty treatment.
- * A case of septic shock in a 55-year-old man from acute cholecystitis, complicated by massive hemolysis, was effectively treated with blood purification, continuous renal replacement therapy, antibiotics, and surgery.
- * The treatment focuses on removing toxins and managing organ damage, with blood purification techniques showing promise despite limited data on their effectiveness for this rare condition.
The Management of Recurrent Urinary Tract Infection: Non-Antibiotic Bundle Treatment.
Probiotics Antimicrob Proteins
October 2024
Recurrent urinary tract infections (rUTIs) are a common condition with high morbidity and negatively impact the quality of life. They account for approximately 25% of all antibiotic prescriptions and are a public health concern in an era of increasing multidrug-resistant organisms (MDROs). Several non-antibiotic treatment strategies have been tried to curb antimicrobial use, and many are effective to some degree, but no experience testing multimodal interventions.
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