Effect of probenecid on the whole-body disposition of 6-bromo-7-[C]methylpurine in humans assessed with long axial field-of-view PET/CT.

Purpose: Multidrug resistance-associated proteins (MRPs) have a widespread tissue distribution. They play an important role in drug disposition and drug-drug interactions (DDIs) and have been associated with various diseases. PET with 6-bromo-7-[C]methylpurine ([C]BMP) has been used to assess MRP1 function in the brain and lungs of mice.

Positron Range Correction Helps Enhance the Image Quality of Cardiac Rb PET/CT.

The image quality and quantitative accuracy of Rb myocardial perfusion imaging (MPI) using PET is challenged by the extensive positron range (PR) effects, with the PR of Rb being about 7 mm in soft tissues. This study explored the feasibility of applying postacquisition PR correction (PRC) to routine Rb PET/CT MPI acquisitions and assessed its impact on diagnostic accuracy and image quality. We implemented a PRC method adjusted to Rb into a vendor-provided reconstruction toolbox, using tissue-specific corrections for soft tissue, bone, and air/lungs.

Quantitative accuracy of preclinical in ovo PET/MRI: influence of attenuation and quantification methods.

Aim: The combination of positron emission tomography (PET) and magnetic resonance imaging (MRI) provides an innovation leap in the use of fertilized chicken eggs (in ovo model) in preclinical imaging as PET/MRI enables the investigation of the chick embryonal organ-specific distribution of PET-tracers. However, hybrid PET/MRI inheres technical challenges in quantitative in ovo PET such as attenuation correction (AC) for the object as well as for additional hardware parts present in the PET field-of-view, which potentially contribute to quantification biases in the PET images if not accounted for. This study aimed to investigate the influence of the different sources of attenuation on in ovo PET/MRI and assess the accuracy of MR-based AC for in ovo experiments.

Development of quantitative PET/MR imaging for measurements of hepatic portal vein input function: a phantom study.

Background: Accurate pharmacokinetic modelling in PET necessitates measurements of an input function, which ideally is acquired non-invasively from image data. For hepatic pharmacokinetic modelling two input functions need to be considered, to account for the blood supply from the hepatic artery and portal vein. Image-derived measurements at the portal vein are challenging due to its small size and image artifacts caused by respiratory motion.

[C]Metoclopramide PET can detect a seizure-induced up-regulation of cerebral P-glycoprotein in epilepsy patients.

Background: P-glycoprotein (P-gp) is an efflux transporter which is abundantly expressed at the blood-brain barrier (BBB) and which has been implicated in the pathophysiology of various brain diseases. The radiolabelled antiemetic drug [C]metoclopramide is a P-gp substrate for positron emission tomography (PET) imaging of P-gp function at the BBB. To assess whether [C]metoclopramide can detect increased P-gp function in the human brain, we employed drug-resistant temporal lobe epilepsy (TLE) as a model disease with a well characterised, regional P-gp up-regulation at the BBB.