Publications by authors named "I Raul Badell"
Article Synopsis
- Fanconi anemia (FA) is a rare genetic disorder marked by varying symptoms and significant chromosome fragility, leading to severe health issues like cancer and bone marrow failure.
- The Spanish Registry of Patients with FA gathered data from 227 patients over 30 years, revealing an 86% cumulative cancer incidence by age 50, with outcomes differing based on chromosome fragility and specific gene mutations.
- Findings suggest that patients with mutations allowing some protein function (genetic hypomorphism) tend to have better health outcomes, indicating potential for new therapies that could enhance mutant FA protein function to improve patient prognosis.
Article Synopsis
- Celiac disease (CD) is an autoimmune disorder triggered by gluten, and its diagnosis relies on genetic tests (HLA-DQ2, DQ8), transglutaminase (TGA) antibodies, and biopsy findings.
- A study involving 112 patients aimed to explore the relationship between TGA levels, genetic markers, and biopsy results, finding that most patients were positive for HLA-DQ2 and showed correlations between TGA levels and intestinal damage.
- The results indicated that older patients tend to have lower TGA levels, and those with severe intestinal damage (Marsh III) correlated with growth failure but not with constipation, highlighting important diagnostic markers for CD.
Haploidentical versus Cord Blood Transplantation in Pediatric AML. A Retrospective Outcome Analysis on Behalf of the Pediatric Subcommittee of GETH (Grupo Español de Trasplante Hematopoyético).
Transplant Cell Ther
October 2024
Haploidentical stem cell transplantation (Haplo-SCT) and cord blood transplantation (CBT) are both effective alternative treatments in patients suffering from acute myeloid leukemia (AML) and lacking a matched HLA donor. In the last years, many centers have abandoned CBT procedures mostly due to concern about poorer immune recovery compared with Haplo-SCT. We conducted a retrospective multicenter study comparing the outcomes using both alternative approaches in AML.
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- - This study examined risk and protective factors for COVID-19 among healthcare workers (HCWs) in Munich, focusing on occupational risks and non-occupational influences.
- - Out of 3,696 vaccinated HCWs, 6.6% had COVID-19, with patient care occupations, community contact with COVID cases, obesity, and frequent travel identified as significant risk factors, while early vaccination, smoking, living with elderly family members, and eating ready-to-eat meals were associated with lower infection rates.
- - The findings suggest that understanding the interplay between living conditions, travel habits, and dietary choices can help improve measures for protecting vulnerable populations from COVID-19.
Belatacept is the first costimulatory blockade agent clinically approved for transplant immunosuppression. Although more than 10 years of study have demonstrated that belatacept offers superior long-term renal allograft and patient survival compared to conventional calcineurin inhibitor (CNI)-based immunosuppression regimens, the clinical adoption of belatacept has continued to lag because of concerns of an early risk of acute cellular rejection (ACR) and various logistical barriers to its administration. In this review, the history of the clinical development of belatacept is examined, along with the findings of the seminal BENEFIT and BENEFIT-EXT trials culminating in the clinical approval of belatacept.
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