Publications by authors named "I R Sequeira"
A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.
View Article and Find Full Text PDFThe oral cavity is a critical barrier with immunosurveillance capabilities. A detailed understanding of its cellular, molecular, and spatial architecture is essential for advancing precision medicine across aerodigestive tissues. Here, we present the first integrated atlas of human adult oral and craniofacial tissues, derived from single-cell RNA sequencing of ~250,000 cells from 70 samples across 13 niches, including salivary glands and oral mucosae.
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- Van der Waals (vdW) moirés can be manipulated to alter electronic properties through a technique that uses heterostrain control in devices.
- By applying strain to a graphene layer over a hexagonal boron nitride substrate, researchers can change the shape and size of the moiré patterns.
- This leads to observable changes in electronic behavior, such as altered resistance peaks, and reveals complex electronic structures that enhance the variety of moiré lattices that can be studied beyond typical twisting methods.
Image-based profiling of the cellular response to drug compounds has proven effective at characterizing the morphological changes resulting from perturbation experiments. As data availability increases, however, there are growing demands for novel deep-learning methods. We applied the SwinV2 computer vision architecture to predict the mechanism of action of 10 kinase inhibitor compounds directly from Cell Painting images.
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- Periodontitis is a widespread condition affecting billions, which led to the creation of a comprehensive single-cell RNA sequencing atlas to study various cell types and microbiomes in the human periodontium.
- The analysis revealed that sulcular and junctional keratinocytes showed significant changes in their behavior and were associated with inflammatory cytokines during periodontitis.
- Advanced techniques identified specific bacteria linked to these keratinocytes and suggested complex interactions within the immune environment that could inform future treatments for chronic inflammation in periodontal disease.