Publications by authors named "I R Rao"
Glomerular filtration rate (GFR) as a marker of kidney function is important in health and disease management because decreased kidney function is associated with all-cause and cardiovascular mortality, progression of kidney disease, predisposition to acute kidney injury (AKI), and for drug dosage modification. While measured glomerular filtration rate (mGFR) is acknowledged as the most accurate method for evaluating kidney function, it is at present not feasible to be applied in the clinical arena. Estimated glomerular filtration rate (eGFR) is preferred due to its convenience, cost-effectiveness, and seamless integration into standard clinical practice for kidney function evaluation.
View Article and Find Full Text PDFStylo (Stylosanthes guianensis) is a tropical legume that exhibits considerable tolerance to manganese (Mn) toxicity, which severely constrains plant growth in acidic soils. To elucidate the Mn detoxification mechanisms in stylo, this study investigated the excess Mn-regulated metabolic profile of stylo roots and examined the role of metabolic enzymes in Mn tolerance. Excess Mn triggered oxidative stress in the two stylo genotypes tested.
View Article and Find Full Text PDFArticle Synopsis
- Chloride levels, often overlooked in critically ill patients, can indicate serious outcomes, such as acute kidney injury (AKI) and major adverse kidney events (MAKE30) in those with sepsis.
- In a study involving 400 sepsis patients, hypochloremia was found to be a significant risk factor for adverse kidney outcomes, with 32.3% of patients showing low chloride levels within 72 hours of ICU admission.
- Conversely, hyperchloremia did not demonstrate any significant association with MAKE30 or worsening AKI, suggesting that low chloride levels are more critical to monitor in sepsis patients.
Article Synopsis
- Haematological abnormalities, particularly post-transplant anemia (PTA), are common among renal transplant recipients, with a peak prevalence of 98% in the first week post-surgery.
- Other issues included leukopenia, thrombocytopenia, and pancytopenia, often caused by medications and infections.
- Despite the high incidence of PTA initially, graft function was stable and similar among patients with and without anemia at six and 12 months post-transplant.
Objectives: The existing biomarkers used to promptly identify graft dysfunction after kidney transplantation lack consistency. Neutrophil gelatinase-associated lipocalin (NGAL) appears to be a promising biomarker but its levels measured from serum and urine have demonstrated varying predictive values. Our study aimed to explore the potential of NGAL as a biomarker in predicting graft dysfunction in kidney transplant patients, including live and deceased donor recipients.
View Article and Find Full Text PDF