Publications by authors named "I R N Verly"
We present a case of laboratory-acquired Salmonella Typhi, resulting in hospitalization of a technician. Blood and stool cultures revealed a S. Typhi strain, identical to the strain with which the employee had recently worked, confirmed using core-genome multilocus sequence typing.
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- * Researchers analyzed urine samples from neuroblastoma patients and controls, measuring various catecholamine metabolites to assess the reliability of spot versus 24-hour urine samples.
- * Results showed that both spot and 24-hour urine samples yielded similar diagnostic sensitivity, leading to the recommendation of using spot urine as the standard method, with a broader panel of metabolites providing better diagnostic accuracy.
Article Synopsis
- * A 3MT gene signature was developed from gene expression data, which successfully predicted poor clinical outcomes, even in low-risk patients, correlating with tumor activity.
- * The study concludes that measuring urinary 3MT at diagnosis can serve as a promising biomarker for assessing risk in neuroblastoma due to its association with increased MYC activity in tumors.
Purpose: Circulating tumor DNA (ctDNA) has been used for disease monitoring in several types of cancer. The aim of our study was to investigate whether ctDNA can be used for response monitoring in neuroblastoma.
Methods: One hundred forty-nine plasma samples from 56 patients were analyzed by quantitative polymerase chain reaction (qPCR) for total cell free DNA (cfDNA; albumin and β-actin) and ctDNA (hypermethylated ).
Introduction: A substantial number of patients with neuroblastoma (NB) have increased excretion of catecholamines and metanephrines. Here, we have investigated the diagnostic role of plasma free metanephrines (PFM), metanephrine (MN), normetanephrine (NMN) and 3-methoxytyramine (3MT) for NB, the most common extra-cranial solid tumour in children.
Methods: PFM were quantified by using a commercial IVD-CE LC-MS/MS method on a TSQ Quantiva coupled to an Ultimate 3000.