Publications by authors named "I R Jorgensen"
Article Synopsis
- The study aimed to explore the presence of risk factors, including genetic variants, in preterm and term-born children with respiratory symptoms.
- A cohort of 63 preterm-born and 86 term-born children was analyzed over six years, revealing that a specific genetic variant increased wheezing risk in term-born children, but not in preterm-born children.
- Parental smoking was found to be a significant risk factor, particularly among preterm-born children with respiratory symptoms.
Article Synopsis
- The study investigates the risk factors and comorbidities related to trigeminal neuralgia, a painful condition affecting facial nerves, highlighting its higher prevalence in women.
- Utilizing data from 7.2 million individuals in Denmark from 1994 to 2018, researchers compared those with trigeminal neuralgia against 10,000 controls to find associated diseases, revealing 27 potential comorbidities linked with the condition.
- It was found that treatment with carbamazepine or oxcarbazepine heightened the risk of ischemic stroke, indicating that healthcare providers should assess vascular risks in patients diagnosed with trigeminal neuralgia.
Quantifying the contribution of genetics and environmental effects on disease initiation and progression, as well as the shared genetics of different diseases, is vital for the understanding of the disease etiology of multimorbidities. In this study, we leverage nationwide Danish registries to provide a granular atlas of the genetic origin of disease phenotypes for a cohort of all Danes 1978-2018 with partially known pedigree (n = 6.3 million).
View Article and Find Full Text PDFStudy Question: How were the logbook and curriculum for the Nurses and Midwives Certification Programme of ESHRE developed?
Summary Answer: The logbook and corresponding curriculum for the ESHRE Nurses and Midwives Certification Programme were based on an extensive literature review, an international expert panel, and a survey of Belgian and Dutch nurses and midwives (N&M) working in reproductive medicine (RM).
What Is Known Already: ESHRE has been running a certification programme for N&M working in RM since 2015. To the best of our knowledge, clinical practice guidelines for nursing/midwifery care within RM are lacking as is consensus on role descriptors of N&M working in RM.
Disease trajectories, defined as sequential, directional disease associations, have become an intense research field driven by the availability of electronic population-wide healthcare data and sufficient computational power. Here, we provide an overview of disease trajectory studies with a focus on European work, including ontologies used as well as computational methodologies for the construction of disease trajectories. We also discuss different applications of disease trajectories from descriptive risk identification to disease progression, patient stratification, and personalized predictions using machine learning.
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