[The significance of individual sensitivity to hypoxia for the duration of severe compression trauma].

In the experiments on rats was shown that individual differences in sensitivity to hypoxia were significant for subsequences of long-term immobilization stress and severe compression trauma. In these conditions, low resistant rats were more sensitive to hypoxia compared with high resistant animals. The low resistant rats had got more significant changes of the main functional systems and acid-alkaline buffer state.

[Efficacy of cytoflavine in treating traumatic toxicosis].

Experiments on rats showed that traumatic toxicosis (crush syndrome) was accompanied with hypotension, bradycardia, reduction in temperature, breath frequency, and oxygen intake, and violation of acid-base buffer state with elevation of lactate acidosis in the blood serum that is typical of shock performance. Substrate combined antihypoxant cytoflavine (1.5 ml/kg) administered systemically to rats immediately after decompression, increased percentage of survived rats and recovered the main indexes of functional systems and acid-base buffer state 12 h after trauma, which provided general protection of rats against traumatic toxicosis.

[Delayed effect of 2-amino-4-acetylthiazolo[5, 4-b]indole hydrobromide on physical capability in mice].

The effect of 2-amino-4-acetylthiazolo[5, 4-b]indole hydrobromide (compound VM-605), a new antihypoxic drug and an analog of antihypoxant amtizole, on physical capability was studied in mice under swimming test conditions. The action of VM-605 depended both on the terms of testing upon administration of the drug and on the psychoemotional type of test animals. Maximum increase of the physical capacity in test mice was observed in delayed (up to 72 h) period after drug injection rather than in early (within 1-3 h) period.

[Effect of cytoflavine on bioenergetic processes in the liver after severe limb compression trauma].

The experiments on rats showed that severe compression trauma of limb muscles leads to a decrease in the energetic potential of the liver. Cytoflavine injected in rats with model traumas increased the content of ATP and cAMP and decreased the level of ADP and AMP, thus recovering the energetic potential of adenine nucleotides in the liver.

[Endovascular surgery and the validation of immunocorrection in patients with liver cirrhosis complicated by portal hypertension].

An analysis of results of complex clinico-immunological studies in 110 patients with liver cirrhosis complicated by portal hypertension has been made. A scheme of immunocorrective therapy with T-activin in patients with liver cirrhosis complicated by portal hypertension is substantiated and developed for performing roentgen endovascular interventions.