Publications by authors named "I Quiroga"
The initial adoption of penicillin as an antibiotic marked the start of exploring other compounds essential for pharmaceuticals, yet resistance to penicillins and their side effects has compromised their efficacy. The N-terminal nucleophile (Ntn) amide-hydrolases S45 family plays a key role in catalyzing amide bond hydrolysis in various compounds, including antibiotics like penicillin and cephalosporin. This study comprehensively analyzes the structural and functional traits of the bacterial N-terminal nucleophile (Ntn) amide-hydrolases S45 family, covering penicillin G acylases, cephalosporin acylases, and D-succinylase.
View Article and Find Full Text PDFImportance: The study summarises the selection prescreen criteria currently used in the UK for a uterus transplant and highlights the number of women who are suitable to proceed.
Objectives: To assess the demographics, motivations, reasons and suitability among women with absolute uterine factor infertility (AUFI) to undergo uterine transplantation (UTx).
Design: A cross-sectional survey.
Article Synopsis
- The study conducted the first genome-wide association study (GWAS) on sporadic Alzheimer's disease (AD) using a sample from Argentina and Chile, involving 539 patients and 854 controls.
- Combining their findings with data from the European Alzheimer and Dementia Biobank (EADB), researchers identified apolipoprotein E ε4 as a significant genetic risk factor and discovered four new loci linked to AD.
- The research highlights the shared genetic factors affecting AD risk across different populations, while also noting that a genetic risk score (GRS) showed diminishing effectiveness with increasing Native American ancestry.
Three-dimensional (3D) chromatin structure has been shown to play a role in regulating gene transcription during biological transitions. Although our understanding of loop formation and maintenance is rapidly improving, much less is known about the mechanisms driving changes in looping and the impact of differential looping on gene transcription. One limitation has been a lack of well-powered differential looping data sets.
View Article and Find Full Text PDFObjective: To assess the motivations and perceptions of the general public in the United Kingdom toward donating their uterus for Uterus Transplantation after death (UTx).
Design: A cross sectional study.
Setting: A 32-item electronic questionnaire.