Publications by authors named "I Putu Mahendra"
Photodynamic therapy has been recognized as a viable approach for lung cancer treatment. Some photosensitizer agents are known as X-ray sensitive and could improve radiotherapy efficacy. The use of nanoparticles for drug delivery and as photosensitizer agents offers various advantages because of their rapid cellular accumulation and distribution into target organs.
View Article and Find Full Text PDFA Combinatorial Approach with Microneedle Pretreatment and Thermosensitive Gel Loaded with Rivastigmine Lipid Nanoparticle Formulation Enables Brain Delivery via the Trigeminal Nerve.
ACS Appl Mater Interfaces
December 2024
Article Synopsis
- Alzheimer's disease leads to cognitive decline and increased care needs; Rivastigmine (RV) is a key treatment limited by the blood-brain barrier (BBB).
- A new method using polymeric microneedles (PMN) and a solid lipid nanoparticle-RV-loaded thermosensitive gel (PMN-SLN-RV-TG) shows potential for better brain delivery compared to traditional methods.
- The study found that PMN-SLN-RV-TG has improved penetration and pharmacokinetic parameters, yielding a higher brain-to-blood ratio and demonstrating safety for brain tissue, indicating a promising alternative for Alzheimer's treatment.
Bacterial cellulose (BC) has gained significant attention as a base material for wound dressings due to its superior physical properties, biocompatibility, and non-toxicity. However, to produce wound dressings that actively facilitate wound healing, BC modification is essential. To provide a comprehensive analysis of the potential research developments and the trends in bacterial cellulose-based wound dressings (BCWD), this review focuses on the BCWD research conducted in the last decade.
View Article and Find Full Text PDFAn inclusive approach: minimizing potential inequality caused by AI.
J Public Health (Oxf)
August 2024