Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers.

Background & Aims: Mutations in the HFE gene can lead to hereditary haemochromatosis (HH) and have been suggested to increase the risk of extra-hepatic diseases, especially breast and colorectal cancer. Here we investigated long-term outcomes of Swedish patients with HFE mutations.

Methods: We identified 3645 patients with a homozygous p.

Symptom pattern following a meal challenge test in patients with irritable bowel syndrome and healthy controls.

Background: Patients with irritable bowel syndrome (IBS) often complain of worsening of symptoms after meal intake. Meal challenge tests have previously been used to study symptoms and pathophysiology in functional dyspepsia.

Objective: The objective of this article is to evaluate differences in gastrointestinal (GI) symptom response to a standardized meal test in IBS compared to healthy controls.

A combined nutrient and lactulose challenge test allows symptom-based clustering of patients with irritable bowel syndrome.

Objectives: The aim of the present pilot study was to evaluate the usefulness of a test meal containing lactulose in the non-invasive assessment of visceral sensitivity in irritable bowel syndrome (IBS), and to identify subsets of IBS patients based on gastrointestinal (GI) symptom generation.

Methods: We included 43 patients with IBS (Rome III) and 29 healthy controls. The fasted subjects were served three test meals consisting of a 400-ml liquid breakfast alone or containing lactulose (15 or 25 g) in a double-blind crossover design.

Randomised clinical trial: symptoms of the irritable bowel syndrome are improved by a psycho-education group intervention.

Background: Evidence supports the effectiveness of cognitive behavioural approaches in improving the symptoms of the irritable bowel syndrome (IBS). Duration, cost and resistance of many patients towards a psychological therapy have limited their acceptance.

Aim: To evaluate the effectiveness of a psycho-educational intervention on IBS symptoms.

Increased TLR2 expression on blood monocytes in irritable bowel syndrome patients.

Objectives: The understanding of the mechanisms for increased immune activation in subgroups of patients with irritable bowel syndrome (IBS) is incomplete. We hypothesized that monocytes are more activated in patients with IBS than in the healthy population. We therefore examined activation phenotype and cytokine secretion of blood monocytes.