Publications by authors named "I Pitarch Castellano"
Sulfoxide synthase OvoA is the key enzyme involved in the biosynthesis of ovothiols (OSHs), secondary metabolites endowed with unique antioxidant properties. Understanding the evolution of such enzymes and the diversity of their metabolites should reveal fundamental mechanisms governing redox signaling and environmental adaptation. "Early-branching" animals such as Cnidaria display unique molecular diversity and symbiotic relationships responsible for the biosynthesis of natural products, however, they have been neglected in previous research on antioxidants and OSHs.
View Article and Find Full Text PDFThird national surgical consensus conference of the Italian Association of Breast Surgeons (ANISC) on management after neoadjuvant chemotherapy: The difficulty in reaching a consensus.
Eur J Surg Oncol
July 2024
Article Synopsis
- Neoadjuvant chemotherapy (NAC) significantly affects breast cancer surgery, leading to a national Consensus Conference by the Italian Association of Breast Surgeons (ANISC) involving various specialists.
- In November 2022, 164 specialists from 74 Breast Centers participated in an online conference to vote on eleven controversial NAC-related issues, achieving consensus on only three.
- The results showed a general agreement on assessing tumor response via MRI, reassessing biological factors of residual tumors, and possibly skipping formal axillary node dissection for certain patients, highlighting the variability in surgical practices post-NAC.
gene mutations occur in approximately 40% of hormone receptor-positive/HER2-negative (HR/HER2) metastatic breast cancers (MBCs), electing them to targeted therapy. Testing status is complex due to selection of biological specimen and testing method. This work investigates real-life experience on testing in HR/HER2 MBC.
View Article and Find Full Text PDFOne of the major threats to skin aging and the risk of developing skin cancer is excessive exposure to the sun's ultraviolet radiation (UVR). The use of sunscreens containing different synthetic, organic, and inorganic UVR filters is one of the most widespread defensive measures. However, increasing evidence suggests that some of these compounds are potentially eco-toxic, causing subtle damage to the environment and to marine ecosystems.
View Article and Find Full Text PDFAim: The analyses here reported aim to compare the screening performance of digital tomosynthesis (DBT) versus mammography (DM).
Methods: MAITA is a consortium of four Italian trials, REtomo, Proteus, Impeto, and MAITA trial. The trials adopted a two-arm randomised design comparing DBT plus DM (REtomo and Proteus) or synthetic-2D (Impeto and MAITA trial) versus DM; multiple vendors were included.