Publications by authors named "I Pichiri"
'Case of the Month' from the University of Verona, Italy-navigating the medical and surgical challenges of urinary bladder paraganglioma: insights from a clinical case.
BJU Int
November 2024
Aims: We investigated quantitative expression, mutual aggregation and relation with hyperglycemia of insulin resistance (IR) and beta-cell dysfunction (BCD) in newly diagnosed type 2 diabetes.
Methods: We assessed IR with euglycemic hyperinsulinemic clamp and BCD with modelled glucose/C-peptide response to oral glucose in 729 mostly drug-naïve patients. We measured glycated hemoglobin, pre-prandial, post-prandial and meal-related excursion of blood glucose.
Article Synopsis
- Nephropathy is a serious complication of type 2 diabetes (T2DM) linked to increased albuminuria and decreased glomerular filtration rate (GFR), with varying progression rates to severe kidney disease among patients.
- In a study of 410 newly diagnosed T2DM patients, researchers tracked changes in eGFR over an average of 12.4 years, finding that about 11.4% experienced rapid declines in eGFR.
- The study concluded that albuminuria is a strong predictor of rapid eGFR decline, which could help in identifying patients at risk and potentially slowing the progression of kidney damage.
Article Synopsis
- The study examined chronic complications in 806 newly diagnosed type 2 diabetes patients at the Verona Diabetes Clinic, focusing on both metabolic and clinical features.
- Comprehensive assessments were conducted to evaluate microvascular and macrovascular complications, including medical history, ECG, imaging tests, and insulin sensitivity analyses.
- Findings revealed that nearly 50% of patients had some form of complications, with key factors such as age, gender, and insulin resistance linked to these issues.
Aim: We aimed to assess the association between decreasing estimated glomerular filtration rate (eGFR) or abnormal albuminuria and the risk of certain cardiac conduction defects in patients with type 2 diabetes mellitus (T2DM).
Methods: We examined a hospital-based sample of 923 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014. Standard electrocardiograms (ECGs) were performed in all patients.