Publications by authors named "I Pergolini"
Objective: Splenectomy is regularly performed in total and distal pancreatectomy due to technical reasons, lymph node dissection and radicality of the operation. However, the spleen serves as an important organ for competent immune function, and its removal is associated with an increased incidence of cancer and a worse outcome in some cancer entities (Haematologica 99:392-398, 2014; Dis Colon Rectum 51:213-217, 2008; Dis Esophagus 21:334-339, 2008). The impact of splenectomy in pancreatic cancer is not fully resolved (J Am Coll Surg 188:516-521, 1999; J Surg Oncol 119:784-793, 2019).
View Article and Find Full Text PDFMast cells are commonly found in pancreatic ductal adenocarcinoma (PDAC), yet their role in the disease remains uncertain. Although mast cells have been associated with depression in several diseases, their connection to PDAC in this context remains unclear. This study explored the correlation between mast cells and psychosocial stress in patients with PDAC.
View Article and Find Full Text PDFArticle Synopsis
- Magnesium (Mg) may help prevent acute pancreatitis by counteracting calcium (Ca)-related signaling pathways that lead to enzyme activation in pancreatic cells.
- A systematic review of 12 studies found that Mg deficiency is often linked to lower calcium levels and acute pancreatitis, and Mg supplementation could mitigate these issues.
- While Mg shows promise in preventing pancreatitis, especially after procedures like ERCP, the varied nature of the studies included makes it difficult to draw strong conclusions.
Article Synopsis
- The study investigates the impact of examined lymph nodes (ELN) on staging and survival in pancreatic ductal adenocarcinoma (PDAC).
- Analyzing data from 341 patients who underwent surgery, they found that examining at least 21 lymph nodes is crucial to accurately determine lymph node involvement.
- Failing to examine 21 or more lymph nodes may lead to misclassification, negatively affecting survival predictions for patients with PDAC.
Background: Arterial resection (AR) during pancreatectomy for curative R0 resection of pancreatic ductal adenocarcinoma (PDAC) remains a controversial procedure with high morbidity.
Objective: To investigate the feasibility and oncological outcomes of pancreatectomy combined with AR at a high-volume center for pancreatic surgery.
Methods: We retrospectively analyzed our experience in PDAC patients, who underwent pancreatic resection with AR and/or venous resection (VR) between 2007 and 2021.