[Significance of the time of administering substance P on learning and memory in rats].

We studied the influence of time and period of application of substance P (SP) on type and size of the effects on learning in Wistar rats. Treatment with SP before acquisition training had a fascillitating effect on learning. If SP was applied from the 1st or 3rd d of acquisition training there was no effect; if given from the 2nd d an inhibition was found; if given from the 4th d the consolidation of memory became finished.