Publications by authors named "I Papassotiriou"
Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR), Growth Differentiation Factor-15 (GDF-15), and Soluble C5b-9 (sC5b-9) Levels Are Significantly Associated with Endothelial Injury Indices in CAR-T Cell Recipients.
Int J Mol Sci
October 2024
Endothelial injury indices, such as Endothelial Activation and Stress Index (EASIX), modified EASIX (m-EASIX), and simplified EASIX (s-EASIX) scores, have been previously associated with chimeric antigen receptor-T (CAR-T) cell immunotherapy complications. Soluble urokinase-type plasminogen activator receptor (suPAR), growth differentiation factor-15 (GDF-15), and soluble C5b-9 (sC5b-9) have been described as markers of endothelial injury post-hematopoietic stem cell transplantation. In the current study, we examined whether suPAR, GDF-15, and sC5b-9 levels were associated with endothelial injury indices in adult CAR-T cell recipients.
View Article and Find Full Text PDFThis systematic review aimed to examine the efficacy and safety profile of amivantamab in patients with advanced or metastatic non-small cell lung cancer (NSCLC) and EGFR mutations. Three scientific databases, PubMed, Cochrane library and ClinicalTrials.gov were searched for relevant articles up until 30 June 2024.
View Article and Find Full Text PDFConsiderations for applying emerging technologies in paediatric laboratory medicine.
Clin Chem Lab Med
September 2024
Emerging technology in laboratory medicine can be defined as an analytical method (including biomarkers) or device (software, applications, and algorithms) that by its stage of development, translation into broad routine clinical practice, or geographical adoption and implementation has the potential to add value to clinical diagnostics. Paediatric laboratory medicine itself may be considered an emerging area of specialisation that is established relatively recently following increased appreciation and understanding of the unique physiology and healthcare needs of the children. Through four clinical (neonatal hypoglycaemia, neonatal hyperbilirubinaemia, sickle cell disorder, congenital adrenal hyperplasia) and six technological (microassays, noninvasive testing, alternative matrices, next generation sequencing, exosome analysis, machine learning) illustrations, key takeaways of application of emerging technology for each area are summarised.
View Article and Find Full Text PDFArticle Synopsis
- Congenital heart disease (CHD) in neonates is linked to coagulation issues that increase morbidity and mortality, with a diverse population making consistent hemostatic patterns hard to identify.
- A study compared hemostatic profiles of 20 neonates with CHD to 18 healthy controls, revealing prolonged prothrombin time and decreased Factor VII in the CHD group, while Factors VIII, von Willebrand factor, and ristocetin cofactor activity were elevated.
- Though ADAMTS-13 levels were lower in CHD patients, this difference wasn't statistically significant, suggesting that while there is a moderately impaired coagulation profile, there's notable variability and heightened thrombogenicity in infants with CHD that needs to be addressed.
Background And Aim: Although lifestyle factors have been repeatedly examined for their role on cardiovascular diseases, their composite effect has not been frequently explored. We aimed to investigate the relation of dietary patterns (DPs) and a health behavior index (HBI) with cardiovascular biomarkers.
Methods And Results: A cross-sectional analysis with data from 3461 US residents, participants in the Health and Retirement Study (HRS), was performed.