Expression of vascular endothelial growth factor (VEGF-A) in rat mandibular salivary gland during paraneoplastic process and treatment with cyclophosphamide and melatonin.

Expression of VEGF-A in Walker 256 carcinosarcoma and mandibular salivary gland of rats during paraneoplastic process and various regimens of chemotherapy with melatonin and cyclophosphamide were studied by immunohistochemical methods. VEGF-A expression increased in the tumor node and salivary gland after monotherapy with melatonin and cyclophosphamide during progression of tumor growth and paraneoplastic syndrome. A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and, especially, after combined treatment, which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action.

Pathomorphological changes in hyaline cartilage during focal persistent infection.

We studied morphological changes in hyaline cartilages of different localization in adult male rabbits with focal persistent infection produced by Staphylococcus aureus strain 209. Local chronic inflammation produced systemic atrophic and degenerative changes in the cartilage tissue. The severity of pathological changes depended on genetically determined repair and metabolic activity of the cartilage tissue.